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es there, which have
been supported by a fellowship from Taiwan's National Science Council. My courses at NYU
are Biochemistry I and II, Molecular Principles of Evolution, Cell Biology, Molecular Controls of
Organism Form and Function, Neuroimmunology Journal Club, and Physiology Basis of
Behavior. I am also researching in Dr. Joseph LeDoux's lab for credit. At this lab, I have been
using immunohistochemistry to detect the activation of track receptors in rat brains after fear
conditioning. One of the tracks, trkB, responds to BDNF, which is related to synaptogenesis
and LTP induction in the processes of learning and memory. My results have shown that the
phosphorylation peak of trk appears in the hippocampal CA1 area 24 hours after fear
conditioning. Further blocking experiments using trk antagonist need to be performed in order
to confirm this result.
My laboratory experience has triggered my strong interest in studying cellular and molecular
mechanisms underlying neurological diseases. The majority of patients with these diseases
have chromosomal and genetic abnormalities. Most genetic diseases lead to neurological
symptoms, and several neurological diseases are associated with strong genetic
predispositions. The genetic defects associated with Alzheimer's Disease, alcoholism,
Fragile-X Syndrome, Neurofibrmatosis, and Parkinson's Disease have already been mapped.
However, the links between genes, gene products, neuronal circuits, brain functions, and
diseases are still unclear. I am eager to help uncover these links.
I think that Mt. Sinai's Ph.D. program perfectly suits my interests. The faculty includes experts
in several divisions of neuroscience. There is an especially large group studying neurological
diseases. The group uses various approaches, animal models, and behavioral paradigms to
search for the causes of diseases on the molecular, cellular, physiological, and system levels. I
am particularly interested in working in Dr. John Morrison's lab, which studies cortical
organizations, glutamate receptors, and neurodegenerative disorders; Dr. Patrick Hof's lab,
which uses comparative neuroanatomy to study aging; Dr. Giulio Pasinetti's lab, which studies
cyclooxygenase and inflammation in Alzheimer's Disease; and Dr. Charles Mobbs's lab, which
uses molecular, histological, behavioral, and electrophysiological methods to study basic
mechanisms underlying metabolic diseases and aging.
Mt. Sinai School of Medicine also attracts me because of its location in an extremely nice area
of Manhattan. In addition, the strong collaboration between its neuroscience program and its
other departments, its affiliated hospital, and many other outstanding New York laboratories
will enable me to receive much technical and academic support.
In order to sponsor my Ph.D. education, I have obtained a competitive Ph.D. fellowship from
the Buddhist Compassion Relief Tzu-Chi Foundation, the largest nonprofit organization in
Taiwan. The foundation is dedicated to helping needy all over the world, regardless of age, sex,
race, and religion. Over the past decades, it has provided worldwide relief and assistance. Its
missions focus on charity, medical care, education, and international relief. The founder,
Master Chang Yang, was once nominated for the Nobel Peace Prize. The foundation will
support my Ph.D. education for at least four years.
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